After suffering a defeat by decison, with his first fight with Erik Morales, Pacquaio on September 10, 2005 at Staples Center, Los Angeles, California, United States, takes on Hector Velasquez.

During the first round Velasquez holds his own, as Pacquiao seemingly started on a slow pace. But after the 2nd round, where Hector Velasquez was outpunched by Manny the Pacman Pacquiao, Velasquez never recovered.

Pacquaio vs Velasquez, came into a conclusion when Velasquez went down just as the bell sounded the end of the 6th round. Referee Lou Moret counted up to eight before declaring the fight TKO.

Manny has now a shot at WBC International super featherweight title, with his rematch with Erik Morales.